For example, germline-inactivating mutations in CDKN1C and epigenetic alterations leading to the loss of imprinting (LOI) (biallelic expression) of IGF2 and silencing of CDKN1C or H19 cause Beckwith–Wiedemann syndrome, a congenital overgrowth disorder associated with susceptibility to embryonal tumours (Maher and Reik, 2000; Weksberg et al, 2003). The gene discussed is CDKN1C; the disease is embryonal neoplasm.