Similarly, analysis of the IG-DMR CpG methylation status in four primary tumours (two neuroblastoma, one phaeochromocytoma and one Wilms' tumour) with GTL2 promoter DMR hypermethylation demonstrated heavy CpG methylation (although less complete than in the neuroblastoma cell lines, possibly because of normal tissue contamination). This evidence concerns the gene MEG3 and neuroblastoma.