In order to investigate whether GTL2 promoter DMR hypermethylation in tumours was associated with alterations in DLK and GTL2 expression and imprinting, we examined the GTL2 promoter DMR methylation status in four neuroblastoma cell lines (SK-N-F1, SK-N-AS, SK-N-DZ, Kelly). The gene discussed is MEG3; the disease is neuroblastoma.