In particular, the imprinted gene cluster at 11p15.5, which contains the paternally expressed insulin-like growth factor (IGF)2 and the maternally expressed CDKN1C and H19 genes has been implicated in disorders of growth and in neoplasia (Maher and Reik, 2000; Feinberg et al, 2002). Here, IGF2 is linked to neoplasm.