On the other hand, the average expression levels of seven genes (Erk1, Mucin 3, Laminin β-3, IGF-2, FAK, MMP-15, and E1AF) and nine genes (Cdc42, Eph, gp130, GST-II, Rho 8, Ras-GAP, p120, MDR1, and Egr-2) were significantly lower and higher, respectively, in the protruded-type adenoma group than in the early invasive carcinoma group (Table 5). The gene discussed is MMP15; the disease is invasive carcinoma.