Increase of apoptosis in glioma C6 in vivo was seen only at high doses of losartan (80 mg Kg−1); this effect was also obtained in cultured C6 cells with the simultaneous administration of losartan and Ang II; it seems that the selective blockage of AT1 may lead to disequilibrium of AT1/AT2 relation that promotes AT2 receptor stimulation which, in turn, could increase its proapoptotic effects. This evidence concerns the gene AGTR2 and central nervous system cancer.