In brain parenchyma there is a local RAAS, some neurons, glial cells and glioma cells express renin, angiotensinogen and receptors for Ang II (AT1 and AT2) (Ganong, 1984, Ariza et al, 1988; Fogarty et al, 2002; Juillerat-Jeanneret et al, 2004). The gene discussed is AGTR1; the disease is central nervous system cancer.