As a result, all three strong positive (3+) cases showed the diffuse-type pattern (Table 3) and had HER-2-positive cells in more than 30% of tumours (Table 4), while most of the weak positive (1+) patients showed that HER-2-positive cells were less than 30% (Table 4) (P=0.057, χ2 analysis). The gene discussed is ERBB2; the disease is neoplasm.