ERBB2 and neoplasm: First, HER-2-positive tumours (1+/2+/3+) analysed by the HercepTest were observed in 30.3% of all patients and HER-2 gene amplification evaluated by FISH was observed in 11.0% of all patients, of which all IHC (3+) tumours were found to have gene amplification and three out of six tumours with moderate positive (2+) tumours showed gene amplification.