ERBB2 and metastatic malignant neoplasm in the lymph nodes: In univariate analysis, the factors such as HER-2 gene amplification, pT2 and pT3, lymph node metastasis, stages 3–4 were significant prognostic factors for survival (Table 6), although only pT2 factor reached to the significant level as independent risk factors for survival in multivariate analysis (Table 6).