Interestingly, pretreatment of NSCLC cell lines with wortmannin, a well-known inhibitor of DNA-PK-dependent NHEJ pathway, increases Rad51 mRNA expression by a factor of about 1.6, but decreases the number of Rad51-positive cells by a factor of about 3 (Figure 3). The gene discussed is PRKDC; the disease is non-small cell lung carcinoma.