By immunohistochemistry numerous markers of neural cell neoplasms (S-100 protein, neurofilament, epithelial membrane antigen, Leu-7 (CD57), neural specific enolase, neuro-peptide substance P, the low-affinity nerve growth factor receptor (p75NGFR), neural cell adhesion molecule (CD56/N-CAM) and growth-associated phosphoprotein-43) have been shown to enhance malignant potential of melanomas and neuronal cell-derived tumors [44-46]. This evidence concerns the gene NCAM1 and melanoma.