Also, therapeutics against individual gene products or a cocktail containing inhibitors for ICAM-1, LFA-3, DC-SIGN, all syndecan isoforms, PPGB, clusterin and other adhesion/membrane proteins important in viral transmission may, alone or in combination with Fuzeon/T20, significantly abrogate the infection of circulating lymphocytes and other cells that are able to support viral infection and replication. The gene discussed is CD58; the disease is viral infectious disease.