In atheroscleropathy and non-diabetic atherosclerosis, the multiple metabolic toxicities and the resultant – parallel ROS, via stimulation of the essential and omnipotent nuclear factor (NFkappaB), which activates the downstream inflammatory mediators TNFalpha, IL-1, IL-6, and other inflammatory markers such as C-reactive protein (CRP). The gene discussed is CRP; the disease is atherosclerosis.