ACE and heart failure: Among participants using ACE inhibitors at baseline, many of whom were likely to have had heart failure, simvastatin allocation significantly reduced the risk of major vascular events (495 [24.9%] simvastatin vs 568 [28.5%] placebo; RR 0.84 [0.75–0.95]; p = 0.006), and there was a non-significant trend towards fewer vascular deaths (265 [13.3%] vs 285 [14.3%]; RR 0.93 [0.78–1.09]; p = 0.4).