We had previously investigated the expression of maspin in gastric cancer and had reported that maspin expression was observed in 80% of gastric cancer tissues and in all gastric normal epithelium with intestinal metaplasia, but not in normal epithelium without intestinal metaplasia, and that expression of maspin was regulated by methylation at the CpG islands of the promoter region (Akiyama et al, 2003). Here, SERPINB5 is linked to gastric cancer.