A study by our group has revealed that 1,25(OH)2D3 and several nonhypercalcemic analogues promote the differentiation and inhibit the proliferation of human colon cancer cells expressing high VDR levels (SW480-ADH) through the induction of E-cadherin and other adhesion proteins and the blockade of β-catenin transcriptional activity (Pálmer et al, 2001) (Figure 1). The gene discussed is VDR; the disease is malignant colon neoplasm.