Previous analyses of high-risk families of different ethnic background yielded a paucity of germline mutations in p53 gene in familial breast cancer: only two mutations were identified among 237 high-risk Norwegian individuals (Borresen et al, 1992), one mutation among 126 high-risk American individuals (Sidransky et al, 1992) and one mutation among 21 families from the UK (Evans et al, 2002). Here, TP53 is linked to breast carcinoma.