Nine NSCLC cell lines (NCI-H460, NCI-H1437, NCI-H2087, NCI-H2122, HCC15, HCC95, HCC366, HCC515, HCC1171) and two SCLC cell lines (NCI-H146, NCI-H211) that showed loss of expression and methylation of SPARC were cultured with the demethylating agent 5-Aza-CdR. Here, SPARC is linked to small cell lung carcinoma.