Transcripts encoding 2 other antigens with cancer-related serological profiles, HSPCA and galectin 4, have been reported to be overexpressed in 45% (20 of 45) (Huang et al, 2004b) and 80% (four of five) (Kondoh et al, 1999) in HCC patients, respectively; their upregulation in HCC may associate with occurrence and progression of tumour. This evidence concerns the gene LGALS4 and cancer.