In IDCs with nodal metastasis, the comparative studies with the PVN classification clearly demonstrated that the NPI, modified NPI, and HG classification were no use in the prediction of the outcome of IDC patients in the multivariate analyses, but in IDCs that are positive for ER and/or PR the pTNM classification showed significant trend P-values for tumour recurrence and death, and especially in stage IIIC cases a significant increase was seen in the HRs of tumour recurrence and death in the multivariate analyses. This evidence concerns the gene PGR and neoplasm.