To analyze the potential role of LT-αβ and TNF-α, two cytokines abundantly expressed in RA synovium and associated with lymphoid neogenesis and GlcNAc6ST-2 expression in transgenic models [3-7,26,28], we examined the effects of the exposure to these cytokines on GlcNAc6ST-2 expression in human endothelial cells lacking the HEC phenotype (HUVEC). Here, CHST4 is linked to rheumatoid arthritis.