Vaccination with CpG-ODN diminished dramatically the number of eosinophils in WT mice while it was only partially effective in prevention of eosinophilia in IFN-β-/- mice, and the difference between the CpG-ODN vaccinated and PBS vaccinated mice was statistically significant for both WT and IFN-β-/- (figure 1B). The gene discussed is IFNB1; the disease is Increased total eosinophil count.