BRCA1 and ovarian cancer: Risk estimates were not markedly different when women with a first primary diagnosis of ovarian cancer were excluded, with a RR (95% CI) for the ≥ 28 CAG cut-point of 0.85 (0.49–1.47) for BRCA1 mutation carriers (P = 0.6), and 1.12 (0.0.55–2.27) for BRCA2 mutation carriers (P = 0.8).