As shown in Fig. 4, a significant inhibition of CD69 expression on RA neutrophils was induced by adalimumab therapy; the inhibition was already evident at week 2 after the start of therapy (%CD69+ cells: 5.5 ± 0.9; MFI: 2.6 ± 0.6; P < 0.01 versus RA baseline) but it was complete at weeks 6 and 12, when no differences were observed between RA patients and control individuals (Fig. 4). This evidence concerns the gene CD69 and rheumatoid arthritis.