Among the cases with MSI and/or immunohistochemical MMR protein loss, 8 metachronous tumors developed and 5/5 analyzed (a leiomyosarcoma, a colon tumor, an endometrial cancer and 2 bladder tumors) displayed MSI and immunohistochemical loss of the concordant MMR protein (table 1). This evidence concerns the gene MRC1 and leiomyosarcoma.