Thus we hypothesised that patients with pSS exhibit specific changes in salivary flow and composition due to presence of focal lymphocytic infiltration in their labial salivary glands (FS) and/or serum autoantibodies to Ro (SSA) and/or La (SSB) antigens (AB) as compared to age- and gender-matched healthy controls with normal salivary gland function. This evidence concerns the gene CALR and peeling skin syndrome.