Because CD36 expression was induced by glucose in PTECs, and because increased CD36 mediated AGE-BSA-, CML-BSA-, and palmitate-induced PTEC apoptosis, we propose a two-step metabolic hit model for TED, a hallmark of progression in DNP. The gene discussed is RENBP; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.