CCL2 and myeloid sarcoma: Based on this model: 1) CCL2 – CCR2 play an important role in the development of inflammatory demyelinating lesions both in EAE and MS; 2) CCL2 expressed in the CNS attracts CCR2+ monocytes and T cells into the developing plaque; 3) while CCR2 binds and internalizes CCL2 molecules in large amounts, CCL2 will be consumed resulting in a reduced CCL2 level in the intercellular fluids and the CSF; 4) when CCR2 encounters its ligand, the CCR2 / CCL2 complex will be internalized and CCR2 will be downregulated on the surface of inflammatory cells in the lesion.