Pashenkov et al [67] studied two secondary lymphoid organ chemokines, CCL19 (exodus-3, MIP-3β) and CCL21 (exodus-2, SCL) in CSF and sera of patients with MS, clinically isolated syndrome (CIS) presenting as optic neuritis (ON), isolated ON, IND and non-inflammatory neurological disease controls (NINC). Here, CCL19 is linked to Down syndrome.