In this study we found significant positive associations between the carriage of the IL10 ATA haplotype, MBL2 codon 54Asp and histologic chorioamnionitis, and negative associations with TNFRSF6 and TGFB1. This is the first study to investigate TNFRSF6 and TGFB1 in combination with such a wide range of cytokine SNPs in histologic acute chorioamnionitis. Here, TGFB1 is linked to chorioamnionitis.