NR3C1 and Cachexia: However, this possibility has largely been discounted, since wasting of body tissues was not prevented by adrenalectomy in mice bearing the MG101 sarcoma (Svaninger et al, 1987), while the glucocorticoid receptor antagonist RU38486 had no effect on the development of cachexia in rats bearing the Yoshida AH-130 hepatoma (Llovera et al, 1996).