Pancreatic cancers not only overexpress multiple growth factors including members of the insulin-like growth factor (IGF) family like IGF-I (Korc, 1998), but also overexpress the intracellular signal transducers of this pathway, IRS-1 and IRS-2 (Kornmann et al, 1998). This evidence concerns the gene IGF1 and familial pancreatic carcinoma.