The patients positive for anti-Hsps were more likely than the antibody-negative group of patients to report a family history of asthma (48.6% Vs 13.8%, p < 0.001) and had higher concentrations of total IgE (758.2 Vs 313.9, P = 0.001) and IL-4 (36.9 Vs 28.5, p = 0.019) (Table 5). This evidence concerns the gene IGHE and asthma.