Gianoulakis Gianoulakis C C Krishnan Krishnan B B Thavundayil Thavundayil J J Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects with high risks of alcoholism Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects with high risks of alcoholism Archives of General Psychiatry Archives of General Psychiatry 53 53 250 250 257 257 1996b 1996b 8611062 8611062. The gene discussed is POMC; the disease is alcohol dependence.