COL18A1 and neoplasm: At 15 min after injection of tumour cells into the spleen, the control mice showed a mean of 7.3±0.6 fluorescent tumour cells per hpf (Figure 3A), whereas in the mice that were treated with endostatin 2 h prior to injection, less arrested intrahepatic cells (3.2±0.5 cells hpf−1) were counted (P<0.001; Figure 3B).