A significant difference in the prevalence of numerical changes was observed in HNSCC of different anatomical sites, with PSCC exhibiting more copy number gains than LSCC and OSCC (CCNL1 and SNO: P<0.001; PIK3CA: P=0.003; TP73L: P=0.007). The gene discussed is CCNL1; the disease is head and neck squamous cell carcinoma.