ERBB2 and neoplasm: In the premenopausal group of women, an increased risk for HER-2/neu-tumours was observed for those women who reported an age at first full pregnancy ≥ 23 years (OR = 3.56, 95%C.I: 1.70–7.46), a BMI>29 kg/m2(OR = 6.89, 95%C.I: 2.23–21.25), first degree family history (OR = 3.30, 95%C.I:1.10–9.96) or use of oral contraceptives (OR = 11.19, 95%C.I 3.70–33.84), while an age at menarche less than 12 years was the only factor which slightly increased the risk in premenopausal HER-2/neu+ patients (OR = 2.09, 95%C.I 0.99–4.42).