Recently, Bid was shown to be negatively regulated by the hypoxia-inducible transcription factor HIF-1 (Erler et al, 2004), and, as cervix carcinoma tumours are known to have variable hypoxic fractions (Nordsmark et al, 2001), it is possible that Bid expression may be linked to HIF-1 activity within tumours. This evidence concerns the gene BID and neoplasm.