RB1 and chronic gastritis: Figure 2B shows significant downregulation of RUNX3 in GCP, and HE staining of corresponding lesions is shown in Figure 2A. In both intestinal metaplasia and chronic gastritis, RUNX3 expression was reduced. RUNX3 expression was decreased to a greater extent near the anastomosis area in the RB group (Figure 2C and D). In contrast, RUNX3 expression was observed mainly distant from the anastomosis area in the RB group (Figure 2E and F).