It has been well established that FGF2 inhibits proliferation of Ewing tumour cell lines in vitro (Schweigerer et al, 1987; Sturla et al, 2000; Westwood et al, 2002) though conflicting results have recently been reported under serum-free culture conditions (Girnita et al, 2000). Here, FGF2 is linked to Ewing sarcoma.