Since adenoma cells appeared to be more resistant to TRAIL than carcinoma cells, experiments were conducted to determine more directly whether TRAIL sensitivity increased in association with malignant progression by comparing the sensitivity of AA/C1, an anchorage-dependent, nontumorigenic, adenoma-derived cell line, and AA/C1/SB/10, an anchorage-independent, tumorigenic derivative of the AA/C1 cell line (Williams et al, 1990). The gene discussed is TNFSF10; the disease is carcinoma.