The loss of heterozygosity for TRAIL-R2 is not reflected in the level of protein in the tumours (Koornstra et al, 2001), and TRAIL-R1 and TRAIL-R2 proteins are overexpressed in colonic tumours relative to normal colonic mucosa (Koornstra et al, 2003). This evidence concerns the gene TNFRSF10B and neoplasm.