TNFSF10 and colorectal carcinoma: Normal colonocytes cultured as intact crypts embedded in collagen have previously been reported to be relatively resistant to TRAIL-induced apoptosis compared to colorectal carcinoma cells (Sträter et al, 2002b), but it is not known whether the sensitivity to TRAIL is acquired early or late in colorectal carcinogenesis, since the response of premalignant adenoma cells to TRAIL has never been examined.