TNFSF10 and malignant colon neoplasm: Although Sheikh et al (1999) reported overexpression of the decoy receptor TRAIL-R3 mRNA in four out of six colon cancers, with TRAIL-R3 overexpression conferring relative TRAIL resistance, Koornstra et al (2003) found no significant alterations in expression of the decoy receptors in colonic tumours compared to normal colonic epithelium in vivo.