The World Health Organization (WHO) recommends initiation of highly active antiretroviral therapy (HAART) in HIV-seropositive infants under the age of 18 months, who have WHO Pediatric Stage III disease and CD4 percentage (%CD4) <20% in resource-poor countries where %CD4 are available but virologic tests (DNA PCR, RT-PCR or immune-complex dissociated p24 antigen) for confirmation of HIV infection are not available [5]. The gene discussed is CD4; the disease is HIV infectious disease.