On the other hand, it can not be excluded that the extend of caspase 3 activation (1.68-fold compared to control) is not high enough to induce apoptosis of TIIcells although a 1.8-fold increase of caspase 3 is combined with apoptosis in total lung of a hyperoxia/pneumonia model [47]. This evidence concerns the gene CASP3 and susceptibility to pneumonia measurement.