FA studies cited here, and other studies described by Meigs [3], have elements in common with our study: 2 to 4 factors were identified; BMI, INS, WHR and WAIST are major contributing risk factors; SBP and DBP load in a separate factor; INS was associated with more than one factor and mainly with obesity and lipids. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.