Although these findings on nimesulide's effects on stroke tempted us to conclude that COX-2 selective inhibitors are less protective in permanent than in transient stroke models, these results should be interpreted with caution since a structurally similar COX-2 inhibitor (NS-398) reduced permanent stroke damage in mice when the treatment started 24 h after MCA occlusion [55] and the same COX-2 inhibitor also reduced lesion size when administered starting 6 h after pMCAO in another previous study [5]. The gene discussed is PTGS2; the disease is Stroke.