However, our present results suggest that in permanent stroke, COX-2 inhibition by nimesulide is not as protective as in transient models (39 % of infarct reduction with pre-treatment in pMCAO vs. 60 % lesion reduction in transient ischemia with immediate treatment) and the therapeutic time window is narrower as compared to temporary occlusion models (2 h in pMCAO vs. 24 h in transient ischemia) as the present results (Tables 1 and 3, Fig. 2) and our recent studies indicate [12]. The gene discussed is PTGS2; the disease is stroke disorder.