The use of antisense oligonucleotides or monoclonal antibodies to EGFR also showed significant inhibition of cancer cell growth (Modjtahedi et al, 1998; Witters et al, 1999), while activation of EGFR family members suppresses the cytotoxic effects of TNF-alpha (Hoffmann et al, 1998). The gene discussed is EGFR; the disease is cancer.