Since shed membrane vesicles exhibit molecules with biologic activity (such as Fas ligand, mdr 1, CD44, and autoreactive tumour antigens) (Taylor et al, 1983b, 1984, 1989, 1996, 2002), the ability of these shed membrane vesicles to modulate lymphocyte and monocyte functions have been analysed in several tumour models. Here, CD44 is linked to neoplasm.