BIRC5 and neoplasm: Moreover, an intriguing association between high expression of nuclear survivin and better chance of performing tumour cytoreduction at first surgery was shown, which is likely to be supported by the association of higher nuclear survivin content with the absence of distinctive patterns that usually preclude the feasibility of cytoreduction, such as tumour involvement of upper abdominal organs and mesentery (Fanfani et al, 2003).