CDH17 and neoplasm: Cadherins comprise a family of transmembrane cell surface glycoproteins that mediate calcium (Ca2+)-dependent, homotypic cell–cell interactions through their extracellular domains, and regulate a variety of biological processes during development, morphogenesis, and tumour metastasis (Gumbiner, 1996; Yap et al, 1997; Conacci-Sorrell et al, 2002).