PTTG1 and neoplasm: bFGF levels were found to be comparatively higher in heart which is consistent with other investigators [41] Taken together our results suggest that over expression of PTTG1 in HEK293 cells results in an increase in secretion and expression of bFGF, VEGF and IL-8 in vitro and in vivo, suggesting that increase in secretion and expression of bFGF, VEGF and IL-8 by PTTG1 may be one of the mechanisms by which PTTG1 achieves its oncogenic function and increases tumor angiogenesis.