IGF2 and breast carcinoma: Breast carcinoma-associated fibroblasts (CAF) have been reported to express increased amounts of specific ECM molecules, various molecules that modulate the ECM, and several peptide growth factors, including insulin-like growth factor (IGF) II, in comparison with fibroblasts in histologically normal breast (i.e. normal breast-associated fibroblasts [NAF]) [1,2].