With reference to the studied immunohistochemical parameters in DCIS/LCIS patients, the Ki-67 value ranged from 10% to 55% (mean ± SD, 33.4 ± 13.4%), p53 ranged from 0% to 27% (mean ± SD, 6.4 ± 8.8%) and c-erbB-2 ranged from 0% to 80% (mean ± SD, 21.7 ± 26.4%) (Table 2). This evidence concerns the gene TP53 and lobular breast carcinoma in situ.