TP53 and breast cancer: The p53 protein showed increasing expression from 11% to 43% at 0.5 μM and 1 μM AZ-1, and then decreased to 31% at the 2 μM concentration of AZ-1, and p21 protein increased from 6% to 22% from the 0.5 μM to 2 μM concentrations of AZ-1 added to BC-M1 cells for 24 hours compared with control, respectively.