Where IGFBP-3 was categorised as positive (1+/2+) or negative (0), the Kaplan-Meier survival curves (Fig. 2) demonstrate a possible trend towards a more favourable outcome for IGFBP-3-negative tumours, although this failed to reach statistical significance for OS (P = 0.168) or DFS (P = 0.269), perhaps related in part to the small numbers of IGFBP-3-negative tumours observed in this study. Here, IGFBP3 is linked to neoplasm.