IGFBP3 and ductal breast carcinoma in situ: We demonstrated an inverse correlation between local IGFBP-3 expression and patient age, in which IGFBP-3 immunoreactivity analysed on a continuum decreased with age (cc -0.214, P = 0.03) (data not shown); Table 1 shows a significant association with age (P = 0.04) when IGFBP-3 and age are analysed categorically in the invasive components, with a possible trend in DCIS (cc -0.174, P = 0.08) (data not shown).