A comparison of categorical IGFBP-3 expression with ER-positive (quick-score 4–8) and ER-negative (quick-score 0–3) IDCs showed a trend (P = 0.06) with ER-negative tumours and HER-2-positive invasive tumours (P = 0.065) (Table 1). This evidence concerns the gene ERBB2 and neoplasm.