IGFBP3 and ductal breast carcinoma in situ: A categorical analysis of individual IGFBP-3 scores (negative versus 1+ versus 2+) in DCIS showed that 97% (32 of 33) of IGFBP-3-positive DCIS were ER-negative versus 80% of ER-positive DCIS (P = 0.037) (Table 1).