In addition to autoantibodies that target the Sm complex, anti-double-stranded DNA (dsDNA), anti-proliferating cell nuclear antigen, anti-U1-RNP, anti-nucleosome, anti-histone, anti-Ro/SS-A, anti-La/SS-B, anti-ribosomal RNP, and anti-phospholipid antibodies are also frequently found in sera from SLE patients [1]. Here, TRIM21 is linked to systemic lupus erythematosus.