In accord with these observations, the microarray data showed early upregulation of genes involved in the NF-κB signalling pathway, such as NF-κB1 (p50 or p105), NFKBIA (IκBα), TNF-α, TNFRSF1a and TNFRSF1b, suggesting a possible regulatory role of NF-κB in the transcription of genes that mediate disease progression in SCW-induced arthritis. Here, NFKB1 is linked to arthritic joint disease.